Rain that isn't rain falls on the Hole — it's magical waste, a black, greasy drizzle bleeding from another world, and it soaks into everything. The streets are a labyrinth of condemned tenements, junk heaps, and open drains, where humans live like roaches under the boot of Sorcerers who cross through conjured doors to use them as disposable lab rats . A man with a lizard's head moves through this mess with a bayonet in each hand and a gas mask strapped over his snout. He doesn't speak for himself. Instead, he shoves a Sorcerer's head into his own jaws, and a second face slides up from his gullet to deliver the only question that matters: "What did the guy inside my mouth say?"

The lizard-man is Caiman, and he has no memory of a life before the scales. His only ally is Nikaido, the woman who runs the Hungry Bug diner — a friend who hides her own lethal secrets and fights bare-knuckled when the knives come out . Together, they hunt magic users in the Hole, severing heads in the hope that one will break the curse. But word of a reptilian mage-killer reaches the Sorcerers' world, and crime boss En, a tycoon whose smoke turns everything into mushrooms, dispatches his "cleaners" — the hammer-swinging Shin and the near-unkillable Noi — to exterminate the anomaly . A two-bit enforcer named Fujita comes along, thirsting for revenge over a murdered partner, and Ebisu, a girl with no face and no memory thanks to Caiman's teeth, stumbles into the grinder . The hunt for identity spirals into a gang war that cracks open the border between worlds, and the thing living inside Caiman's throat may not be a clue — it may be the monster who started all of this.

Also known as: ドロヘドロ, Dorohedoro.